Paper Info
Title
Reactant and Waste Minimization in Multitarget Sample Preparation on Digital Microfluidic Biochips
Abstract
Sample preparation is one of essential processes in biochemical reactions. Raw reactants are diluted in this process to achieve given target concentrations. A bioassay may require several different target concentrations of a reactant. Both the dilution operation count and the reactant usage can be minimized if multiple target concentrations are considered simultaneously during sample preparation. Hence, in this paper, we propose a multitarget sample preparation algorithm that extensively exploits the ideas of waste recycling and intermediate droplet sharing to reduce both reactant usage and waste amount for digital microfluidic biochips. Experimental results show that our waste recycling algorithm can reduce the waste and operation count by 48% and 37%, respectively, as compared to an existing state-of-the-art multitarget sample preparation method if the number of target concentrations is ten. The reduction can be up to 97% and 73% when the number of target concentrations goes even higher.
Year
DOI
Venue
2013
10.1109/TCAD.2013.2263035
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Keywords
DocType
Volume
intermediate droplet sharing,waste minimization,digital microfluidic biochip (dmfb),waste reduction,biochemical reactions,recycling,multitarget sample preparation,bioassay,biochemistry,waste recycling,dilution operation count,biochip,digital microfluidic biochips,lab-on-a-chip,microfluidics,dilution,target concentrations,reactant minimization
Journal
32
Issue
ISSN
Citations 
10
0278-0070
22
PageRank 
References 
Authors
0.92
17
3
Name
Order
Citations
PageRank
Juinn-Dar Huang127027.42
Chia-Hung Liu21699.57
Huei-Shan Lin3525.37